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CXCR4

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protéine

Resous ekstèn

idantifyan sou Freebase
/m/07b_jk[1]
identifiant Microsoft Academic
129470790
identifiant Medical Subject Headings
D019718

sous le nom: Receptors, CXCR4

arborescence MeSH
D12.776.543.750.695.160.500.400
D12.776.543.750.705.852.125.500.400
D12.776.543.750.830.700.650
identifiant RefSeq
NP_001008540[2]
NP_003458[2]
NP_001334985[2]
NP_001334988[2]
NP_001334989[2]
Transporter Classification Database ID
9.A.14.13.17[3][4]
UMLS CUI
C0250501[5]
identifiant Ensembl de la protéine
ENSP00000386884[6]
ENSP00000241393[7]
identifiant Protein Data Bank
4RWS[8]
2K03[8]
2K04[8]
2K05[8]
3ODU[8]
3OE0[8]
3OE6[8]
3OE8[8]
3OE9[8]
2N55[8]
identifiant OpenAlex
C129470790[9]
identifiant UniProt d'une protéine
P61073[10]

se yon

proteyin[10]

pati de

CXC chemokine receptor 4/atypical chemokine receptor 2[11]
récepteurs couplés aux protéines G[12]
GPCR, rhodopsin-like, 7TM, protein family[13]
CXC chemokine receptor 4 N-terminal domain, protein family[13]

trouvé dans le taxon

Homo sapiens[10]

codé par

CXCR4[10]

fonction moléculaire

cytokine binding[14]

méthode de détermination: IEA

coreceptor activity[15]

méthode de détermination: TAS

virus receptor activity[16]

méthode de détermination: IEA

signal transducer activity[17]

méthode de détermination: IEA

liaison protéique[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]

méthode de détermination: IPI

chemokine receptor activity[14]

méthode de détermination: IEA

myosin light chain binding[33]

méthode de détermination: IDA

actin binding[33]

méthode de détermination: IDA

ubiquitin protein ligase binding[34]

méthode de détermination: IPI

G protein-coupled receptor activity[35][16][14]

méthode de détermination: IEA, TAS

C-X-C chemokine receptor activity[36]

méthode de détermination: NAS

ubiquitin binding[37]

méthode de détermination: IDA

C-C chemokine binding[38]

méthode de détermination: IPI

C-C chemokine receptor activity[39]

méthode de détermination: IBA

chemokine binding[39]

méthode de détermination: IBA

C-C chemokine binding[40][39]

méthode de détermination: IBA, IPI

C-X-C motif chemokine 12 receptor activity[41]

méthode de détermination: IDA

C-X-C chemokine receptor activity[42][43]

méthode de détermination: IEA, NAS

composant cellulaire

Sitoplas[44]

méthode de détermination: TAS

integral component of membrane[16][14]

méthode de détermination: IEA

endosome[16][43]

méthode de détermination: IEA

membrane[16]

méthode de détermination: IEA

surface cellulaire[45][46][47][48][49]

méthode de détermination: IDA

jonction cellulaire[16]

méthode de détermination: IEA

cell leading edge[33]

méthode de détermination: IDA

exosome[50]

méthode de détermination: IDA

vésicule cytoplasmique[46][45]

méthode de détermination: IDA

early endosome[16][51][52]

méthode de détermination: IEA, IDA

late endosome[16][52]

méthode de détermination: IEA, IDA

lysosome[16][51][52]

méthode de détermination: IEA, IDA

Manbràn selilè[53][54][16][43][52]

méthode de détermination: IEA, TAS, IDA

external side of plasma membrane[39]

méthode de détermination: IBA

complexe macromoléculaire[55]

méthode de détermination: IMP

exosome[56]

méthode de détermination: HDA

Nwayo[43]

méthode de détermination: IEA

Sitoplas[57][43]

méthode de détermination: IEA, TAS

processus biologique

myelin maintenance[58]

méthode de détermination: ISS

positive regulation of oligodendrocyte differentiation[58]

méthode de détermination: ISS

response to hypoxia[59]

méthode de détermination: IEP

positive regulation of cytosolic calcium ion concentration[60]

méthode de détermination: TAS

chemokine-mediated signaling pathway[61]

méthode de détermination: IEA

response to virus[62]

méthode de détermination: TAS

dendritic cell chemotaxis[63]

méthode de détermination: TAS

cellular response to cytokine stimulus[52]

méthode de détermination: IDA

chimiotaxie[64]

méthode de détermination: IEA

réponse inflammatoire[35]

méthode de détermination: TAS

calcium-mediated signaling[65]

méthode de détermination: IMP

transduction de signal[16]

méthode de détermination: IEA

apoptose[66]

méthode de détermination: TAS

viral process[16]

méthode de détermination: IEA

fusion of virus membrane with host plasma membrane[53]

méthode de détermination: TAS

regulation of chemotaxis[67]

méthode de détermination: IMP

G protein-coupled receptor signaling pathway[53][16][14][47]

méthode de détermination: IDA, IEA, TAS

Guidage axonal[53]

méthode de détermination: TAS

chimiotaxie[14][39]

méthode de détermination: IBA, IEA

réponse immunitaire[39]

méthode de détermination: IBA

positive regulation of cytosolic calcium ion concentration[68][39]

méthode de détermination: IBA, TAS

développement cérébral[39]

méthode de détermination: IBA

calcium-mediated signaling[69][39]

méthode de détermination: IBA, IMP

neurogenèse[70]

méthode de détermination: IBA

CXCL12-activated CXCR4 signaling pathway[71][41]

méthode de détermination: IDA, IMP

cell chemotaxis[39]

méthode de détermination: IBA

positive regulation of cold-induced thermogenesis[72]

méthode de détermination: ISS

regulation of cell adhesion[73]

méthode de détermination: IDA

migration d'un neurone[43]

méthode de détermination: IEA

epithelial cell development[43]

méthode de détermination: IEA

neuron recognition[43]

méthode de détermination: IEA

response to activity[43]

méthode de détermination: IEA

migration cellulaire[43]

méthode de détermination: IEA

neurogenèse[43][39]

méthode de détermination: IBA, IEA

telencephalon cell migration[43]

méthode de détermination: IEA

positive regulation of cell migration[43]

méthode de détermination: IEA

positive regulation of vascular wound healing[43]

méthode de détermination: IEA

regulation of programmed cell death[43]

méthode de détermination: IEA

response to morphine[43]

méthode de détermination: IEA

endothelial cell differentiation[43]

méthode de détermination: IEA

positive regulation of neurogenesis[43]

méthode de détermination: IEA

regulation of viral process[43]

méthode de détermination: IEA

regulation of chemotaxis[74][43]

méthode de détermination: IEA, IMP

positive regulation of chemotaxis[43]

méthode de détermination: IEA

detection of temperature stimulus involved in sensory perception of pain[43]

méthode de détermination: IEA

detection of mechanical stimulus involved in sensory perception of pain[43]

méthode de détermination: IEA

regulation of calcium ion transport[43]

méthode de détermination: IEA

cardiac muscle contraction[43]

méthode de détermination: IEA

endothelial tube morphogenesis[43]

méthode de détermination: IEA

positive regulation of dendrite extension[43]

méthode de détermination: IEA

positive regulation of mesenchymal stem cell migration[43]

méthode de détermination: IEA

response to ultrasound[43]

méthode de détermination: IEA

interagit physiquement avec

Plerixafor[75]

usage: antagoniste de récepteur

mavorixafor[76]

rôle de l'objet: antagoniste de récepteur

image du Gene Atlas

correspondance exacte

http://purl.uniprot.org/uniprot/P61073[77]

comprend

GPCR, rhodopsin-like, 7TM[11]
CXC chemokine receptor 4 N-terminal domain[11]

catégorie Commons

CXCR4 receptors

Referans

  1. ↑ sauvegarde de la base de données Freebase, 28 oktòb 2013
  2. ↑ 2,0 2,1 2,2 2,3 et 2,4 NCBI Gene, 30 me 2020, 7852
  3. ↑ TCDB, 13 mas 2020
  4. ↑ TCDB, 29 avril 2020
  5. ↑ UMLS 2023, 25 me 2023, inferred by common MeSH mappings on source and on Wikidata
  6. ↑ Ensembl Release 99, ENSP00000386884
  7. ↑ Ensembl Release 99, ENSP00000241393
  8. ↑ 8,00 8,01 8,02 8,03 8,04 8,05 8,06 8,07 8,08 et 8,09 P61073, 9 out 2016, UniProt, angle
  9. ↑ OpenAlex, 26 janvye 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  10. ↑ 10,0 10,1 10,2 et 10,3 UniProt, 13 novanm 2019, P61073
  11. ↑ 11,0 11,1 et 11,2 InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P61073
  12. ↑ 9.A.14.13.17, 2 oktòb 2019, hierarchical database ID heuristic
  13. ↑ 13,0 et 13,1 inferred from protein domain or family
  14. ↑ 14,0 14,1 14,2 14,3 14,4 et 14,5 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, InterPro, GOA
  15. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Proteome Inc., Engagement of CD28 modulates CXC chemokine receptor 4 surface expression in both resting and CD3-stimulated CD4+ T cells, GOA
  16. ↑ 16,00 16,01 16,02 16,03 16,04 16,05 16,06 16,07 16,08 16,09 16,10 16,11 et 16,12 IEA, 8 avril 2019, P61073, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  17. ↑ IEA, 31 oktòb 2017, P61073, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073, UniProt
  18. ↑ IPI, 8 avril 2019, P61073, beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  19. ↑ IPI, 8 avril 2019, P61073, Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  20. ↑ IPI, 8 avril 2019, P61073, RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  21. ↑ IPI, 8 avril 2019, P61073, Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  22. ↑ IPI, 8 avril 2019, P61073, Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  23. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, Actin-binding protein drebrin regulates HIV-1-triggered actin polymerization and viral infection, GOA
  24. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation, GOA
  25. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, CXCR4-CCR5: a couple modulating T cell functions, GOA
  26. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5, GOA
  27. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes, GOA
  28. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, A functional heteromeric MIF receptor formed by CD74 and CXCR4, GOA
  29. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function, GOA
  30. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4, GOA
  31. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse, GOA
  32. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, CD164 regulates the tumorigenesis of ovarian surface epithelial cells through the SDF-1α/CXCR4 axis, GOA
  33. ↑ 33,0 33,1 et 33,2 IDA, 8 avril 2019, P61073, Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  34. ↑ IPI, 8 avril 2019, P61073, The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  35. ↑ 35,0 et 35,1 TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Proteome Inc., Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes, GOA
  36. ↑ NAS, 1 janvye 2018, P61073, Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  37. ↑ IDA, 8 avril 2019, P61073, CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  38. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073, 31 oktòb 2017, Critical Assessment of Protein Function Annotation, Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine, GOA
  39. ↑ 39,00 39,01 39,02 39,03 39,04 39,05 39,06 39,07 39,08 39,09 et 39,10 IBA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, GO Central, Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium, GOA
  40. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Critical Assessment of Protein Function Annotation, Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine, GOA
  41. ↑ 41,0 et 41,1 IDA, 8 avril 2019, P61073, RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  42. ↑ NAS, 8 avril 2019, P61073, Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  43. ↑ 43,00 43,01 43,02 43,03 43,04 43,05 43,06 43,07 43,08 43,09 43,10 43,11 43,12 43,13 43,14 43,15 43,16 43,17 43,18 43,19 43,20 43,21 43,22 43,23 43,24 43,25 43,26 43,27 et 43,28 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Ensembl, GOA
  44. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 1 janvye 2018, Proteome Inc., Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS, GOA
  45. ↑ 45,0 et 45,1 IDA, 8 avril 2019, P61073, Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  46. ↑ 46,0 et 46,1 IDA, 8 avril 2019, P61073, Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  47. ↑ 47,0 et 47,1 IDA, 8 avril 2019, P61073, beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  48. ↑ IDA, 8 avril 2019, P61073, CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  49. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Mouse Genome Informatics, CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration, GOA
  50. ↑ IDA, 31 oktòb 2017, P61073, MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073, UniProt
  51. ↑ 51,0 et 51,1 IDA, 8 avril 2019, P61073, The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  52. ↑ 52,0 52,1 52,2 52,3 et 52,4 IDA, 8 avril 2019, P61073, Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  53. ↑ 53,0 53,1 53,2 et 53,3 TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Reactome, GOA
  54. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Proteome Inc., Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors, GOA
  55. ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Critical Assessment of Protein Function Annotation, Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine, GOA
  56. ↑ HDA, 8 avril 2019, P61073, MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  57. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Proteome Inc., Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS, GOA
  58. ↑ 58,0 et 58,1 ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, British Heart Foundation, GOA
  59. ↑ IEP, 8 avril 2019, P61073, Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  60. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073, 31 oktòb 2017, Proteome Inc., Down-regulation of CXCR4 by human herpesvirus 6 (HHV-6) and HHV-7, GOA
  61. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073, 31 oktòb 2017, Gene Ontology Consortium, GOA
  62. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Proteome Inc., Use of chemokine receptors by poxviruses, GOA
  63. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, British Heart Foundation, The multiple personalities of the chemokine receptor CCR7 in dendritic cells, GOA
  64. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073, 31 oktòb 2017, InterPro, GOA
  65. ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073, 31 oktòb 2017, Mouse Genome Informatics, Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines, GOA
  66. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Proteome Inc., HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases, GOA
  67. ↑ IMP, 1 janvye 2018, P61073, Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  68. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Proteome Inc., Down-regulation of CXCR4 by human herpesvirus 6 (HHV-6) and HHV-7, GOA
  69. ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Mouse Genome Informatics, Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines, GOA
  70. ↑ IBA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 1 janvye 2018, GO Central, Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium, GOA
  71. ↑ IMP, 8 avril 2019, P61073, The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom's Macroglobulinemia., GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  72. ↑ ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, YuBioLab, Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity, GOA
  73. ↑ IDA, 8 avril 2019, P61073, Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4., GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  74. ↑ IMP, 8 avril 2019, P61073, Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
  75. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 out 2016, 844, angle
  76. ↑ Open Targets Platform, 14 out 2023, https://platform.opentargets.org/drug/CHEMBL518924
  77. ↑ Identifiers.org
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