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Interleukine 6

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protéine humaine

Resous ekstèn

idantifyan sou Freebase
/m/05gpxj[1]
identifiant RefSeq
NP_000591[2]
NP_001305024[2]
XP_005249802[2]
XP_011513692[2]
NP_001358025[2]
identifiant Protein Data Bank
4O9H[3]
1ALU[3]
1IL6[3]
1P9M[3]
2IL6[3]
4CNI[3]
4J4L[3]
4NI7[3]
4NI9[3]
4ZS7[3]
identifiant Ensembl de la protéine
ENSP00000385675[4]
ENSP00000258743[5]
ENSP00000384928[6]
ENSP00000385043[7]
ENSP00000385227[8]
ENSP00000385718[9]
ENSP00000405150[10]
identifiant Microsoft Academic
11988809
identifiant UniProt d'une protéine
P05231[11]
identifiant Bibliothèque nationale centrale de Florence
73989
identifiant OpenAlex
C11988809[12]

se yon

proteyin[11]

pati nan

interleukin-6[13]
four-helical cytokine-like, core[13]
Interleukin-6/GCSF/MGF, conserved site, protein family[14]

trouvé dans le taxon

Homo sapiens[11]

codé par

IL6[11]

fonction moléculaire

cytokine activity[15][16][17][18][19][20]

méthode ou standard de détermination: NAS, IDA, ISS, IEA

growth factor activity[21][17][22][23]

méthode ou standard de détermination: IDA, IEA, TAS

interleukin-6 receptor binding[24][25][26][18]

méthode ou standard de détermination: NAS, IEA, TAS, IPI

liaison protéique[27][28][29][30][31]

méthode ou standard de détermination: IPI

composant cellulaire

région extracellulaire[32][17][18]

méthode ou standard de détermination: IEA, TAS

interleukin-6 receptor complex[22][33]

méthode ou standard de détermination: IDA

milieu extracellulaire[17][34][35][20]

méthode ou standard de détermination: IDA, IEA

endoplasmic reticulum lumen[32]

méthode ou standard de détermination: TAS

processus biologique

regulation of angiogenesis[36]

méthode ou standard de détermination: IC

positive regulation of translation[37]

méthode ou standard de détermination: IDA

platelet activation[38]

méthode ou standard de détermination: TAS

humoral immune response[39]

méthode ou standard de détermination: IC

defense response to virus[20]

méthode ou standard de détermination: IDA

response to peptidoglycan[40]

méthode ou standard de détermination: NAS

neuron projection development[41]

méthode ou standard de détermination: IMP

defense response to Gram-positive bacterium[42]

méthode ou standard de détermination: TAS

negative regulation of fat cell differentiation[43]

méthode ou standard de détermination: NAS

positive regulation of peptidyl-serine phosphorylation[44]

méthode ou standard de détermination: IDA

positive regulation of leukocyte chemotaxis[42]

méthode ou standard de détermination: TAS

positive regulation of T cell proliferation[45]

méthode ou standard de détermination: IDA

positive regulation of interleukin-6 production[46]

méthode ou standard de détermination: IDA

positive regulation of peptidyl-tyrosine phosphorylation[44]

méthode ou standard de détermination: IDA

positive regulation of acute inflammatory response[47]

méthode ou standard de détermination: IDA

réponse inflammatoire[35]

méthode ou standard de détermination: IDA

negative regulation of collagen biosynthetic process[48]

méthode ou standard de détermination: IDA

positive regulation of MAPK cascade[44][48]

méthode ou standard de détermination: IDA

hepatic immune response[49][47]

méthode ou standard de détermination: IDA, TAS

monocyte chemotaxis[50]

méthode ou standard de détermination: IC

positive regulation of DNA-binding transcription factor activity[51]

méthode ou standard de détermination: IDA

negative regulation of apoptotic process[52]

méthode ou standard de détermination: IDA

positive regulation of osteoblast differentiation[53]

méthode ou standard de détermination: TAS

positive regulation of NF-kappaB transcription factor activity[48]

méthode ou standard de détermination: IDA

acute-phase response[49][17]

méthode ou standard de détermination: IEA, TAS

réponse immunitaire[18]

méthode ou standard de détermination: IEA

regulation of vascular endothelial growth factor production[54]

méthode ou standard de détermination: IDA

positive regulation of chemokine production[40][46]

méthode ou standard de détermination: NAS, IDA

negative regulation of lipid storage[43]

méthode ou standard de détermination: NAS

neutrophil mediated immunity[42]

méthode ou standard de détermination: TAS

positive regulation of smooth muscle cell proliferation[46]

méthode ou standard de détermination: IDA

positive regulation of type B pancreatic cell apoptotic process[55]

méthode ou standard de détermination: TAS

response to glucocorticoid[35]

méthode ou standard de détermination: IDA

defense response to Gram-negative bacterium[42]

méthode ou standard de détermination: TAS

positive regulation of cell population proliferation[56][22]

méthode ou standard de détermination: IDA, IMP

positive regulation of apoptotic process[57]

méthode ou standard de détermination: IDA

positive regulation of B cell activation[19]

méthode ou standard de détermination: IDA

modification post-traductionnelle[32]

méthode ou standard de détermination: TAS

regulation of signaling receptor activity[58]

méthode ou standard de détermination: IEA

positive regulation of tyrosine phosphorylation of STAT protein[23][59]

méthode ou standard de détermination: IDA

neutrophil apoptotic process[52]

méthode ou standard de détermination: IDA

negative regulation of cell population proliferation[60]

méthode ou standard de détermination: TAS

positive regulation of gene expression[59]

méthode ou standard de détermination: IDA

endocrine pancreas development[16]

méthode ou standard de détermination: ISS

negative regulation of bone resorption[16]

méthode ou standard de détermination: ISS

régulation positive de la transcription dépendante de l'ADN[61][62][51]

méthode ou standard de détermination: IDA, IMP

positive regulation of transcription by RNA polymerase II[16][44][63][64]

méthode ou standard de détermination: IDA, ISS

glucagon secretion[16]

méthode ou standard de détermination: ISS

cellular response to hydrogen peroxide[65]

méthode ou standard de détermination: IDA

cellular response to lipopolysaccharide[66]

méthode ou standard de détermination: IMP

T-helper 17 cell lineage commitment[67]

méthode ou standard de détermination: ISS

positive regulation of T-helper 2 cell cytokine production[16]

méthode ou standard de détermination: ISS

negative regulation of interleukin-1-mediated signaling pathway[16]

méthode ou standard de détermination: ISS

cytokine-mediated signaling pathway[32][22][23]

méthode ou standard de détermination: IDA, TAS

interleukin-6-mediated signaling pathway[32][63][68]

méthode ou standard de détermination: IDA, TAS

positive regulation of receptor signaling pathway via JAK-STAT[64][48][68][69]

méthode ou standard de détermination: IC, IDA

correspondance exacte

http://purl.uniprot.org/uniprot/P05231[70]

comprend

Interleukin-6/GCSF/MGF, conserved site[13]

Referans

  1. ↑ sauvegarde de la base de données Freebase, 28 oktòb 2013
  2. ↑ 2,0 2,1 2,2 2,3 et 2,4 NCBI Gene, 30 me 2020, 3569
  3. ↑ 3,00 3,01 3,02 3,03 3,04 3,05 3,06 3,07 3,08 et 3,09 P05231, 9 out 2016, angle, UniProt
  4. ↑ Ensembl Release 99, ENSP00000385675
  5. ↑ Ensembl Release 99, ENSP00000258743
  6. ↑ Ensembl Release 99, ENSP00000384928
  7. ↑ Ensembl Release 99, ENSP00000385043
  8. ↑ Ensembl Release 99, ENSP00000385227
  9. ↑ Ensembl Release 99, ENSP00000385718
  10. ↑ Ensembl Release 99, ENSP00000405150
  11. ↑ 11,0 11,1 11,2 et 11,3 UniProt, 13 novanm 2019, P05231
  12. ↑ OpenAlex, 26 janvye 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  13. ↑ 13,0 13,1 et 13,2 InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P05231
  14. ↑ inferred from protein domain or family
  15. ↑ British Heart Foundation, 27 mas 2018, Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor, GOA, NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  16. ↑ 16,0 16,1 16,2 16,3 16,4 16,5 et 16,6 British Heart Foundation, 27 mas 2018, GOA, ISS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  17. ↑ 17,0 17,1 17,2 17,3 et 17,4 GOA, 27 mas 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IEA
  18. ↑ 18,0 18,1 18,2 et 18,3 InterPro, 27 mas 2018, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  19. ↑ 19,0 et 19,1 British Heart Foundation, 27 mas 2018, Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  20. ↑ 20,0 20,1 et 20,2 British Heart Foundation, 27 mas 2018, Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  21. ↑ Proteome Inc., 27 mas 2018, Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6), GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  22. ↑ 22,0 22,1 22,2 et 22,3 British Heart Foundation, 27 mas 2018, Molecular cloning and expression of an IL-6 signal transducer, gp130, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  23. ↑ 23,0 23,1 et 23,2 British Heart Foundation, 27 mas 2018, Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  24. ↑ Proteome Inc., 27 mas 2018, Loss of IL-6 receptor expression in cervical carcinoma cells inhibits autocrine IL-6 stimulation: abrogation of constitutive monocyte chemoattractant protein-1 production, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  25. ↑ Marked cell-type-specific differences in glycosylation of human interleukin-6, GOA, 27 mas 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, NAS
  26. ↑ British Heart Foundation, 27 mas 2018, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  27. ↑ IntAct protein interaction database, 27 mas 2018, Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  28. ↑ IntAct protein interaction database, 27 mas 2018, Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  29. ↑ IntAct protein interaction database, 27 mas 2018, A human protein-protein interaction network: a resource for annotating the proteome, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  30. ↑ IntAct protein interaction database, 27 mas 2018, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  31. ↑ IntAct protein interaction database, 27 mas 2018, Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  32. ↑ 32,0 32,1 32,2 32,3 et 32,4 Reactome, 27 mas 2018, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  33. ↑ British Heart Foundation, 27 mas 2018, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  34. ↑ British Heart Foundation, 27 mas 2018, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  35. ↑ 35,0 35,1 et 35,2 British Heart Foundation, 27 mas 2018, Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  36. ↑ British Heart Foundation, 27 mas 2018, Interleukin 6 induces the expression of vascular endothelial growth factor, GOA, IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  37. ↑ BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription, GOA, 27 mas 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IDA
  38. ↑ British Heart Foundation, 27 mas 2018, Platelet activation induced by interleukin-6: evidence for a mechanism involving arachidonic acid metabolism, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  39. ↑ British Heart Foundation, 27 mas 2018, Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin, GOA, IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  40. ↑ 40,0 et 40,1 British Heart Foundation, 27 mas 2018, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA, NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  41. ↑ British Heart Foundation, 27 mas 2018, Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6, GOA, IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  42. ↑ 42,0 42,1 42,2 et 42,3 British Heart Foundation, 27 mas 2018, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  43. ↑ 43,0 et 43,1 British Heart Foundation, 27 mas 2018, Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes, GOA, NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  44. ↑ 44,0 44,1 44,2 et 44,3 Mouse Genome Informatics, 27 mas 2018, Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  45. ↑ British Heart Foundation, 27 mas 2018, Synergistic activation of human T cells by interleukin 1 and interleukin 6, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  46. ↑ 46,0 46,1 et 46,2 British Heart Foundation, 27 mas 2018, Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  47. ↑ 47,0 et 47,1 British Heart Foundation, 27 mas 2018, Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  48. ↑ 48,0 48,1 48,2 et 48,3 British Heart Foundation, 27 mas 2018, JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  49. ↑ 49,0 et 49,1 British Heart Foundation, 27 mas 2018, Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE), GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  50. ↑ British Heart Foundation, 27 mas 2018, Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor, GOA, IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  51. ↑ 51,0 et 51,1 British Heart Foundation, 27 mas 2018, Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  52. ↑ 52,0 et 52,1 Interleukin-6 suppression of neutrophil apoptosis is neutrophil concentration dependent, GOA, 27 mas 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IDA
  53. ↑ British Heart Foundation, 27 mas 2018, Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  54. ↑ British Heart Foundation, 27 mas 2018, Interleukin 6 induces the expression of vascular endothelial growth factor, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  55. ↑ British Heart Foundation, 27 mas 2018, Interleukin-6 regulates pancreatic alpha-cell mass expansion, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  56. ↑ British Heart Foundation, 27 mas 2018, Interleukin-6 regulates pancreatic alpha-cell mass expansion, GOA, IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  57. ↑ Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells, GOA, 27 mas 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IDA
  58. ↑ Gene Ontology Consortium, 27 mas 2018, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  59. ↑ 59,0 et 59,1 British Heart Foundation, 27 mas 2018, Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  60. ↑ Proteome Inc., 27 mas 2018, Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  61. ↑ Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma, GOA, 27 mas 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IMP
  62. ↑ B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma, GOA, 27 mas 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, IDA
  63. ↑ 63,0 et 63,1 British Heart Foundation, 27 mas 2018, STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  64. ↑ 64,0 et 64,1 British Heart Foundation, 27 mas 2018, Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  65. ↑ British Heart Foundation, 27 mas 2018, IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  66. ↑ Mouse Genome Informatics, 27 mas 2018, SASH1 is a scaffold molecule in endothelial TLR4 signaling, GOA, IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  67. ↑ GOA, 27 mas 2018, P05231, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ISS
  68. ↑ 68,0 et 68,1 British Heart Foundation, 27 mas 2018, Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  69. ↑ British Heart Foundation, 27 mas 2018, Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells, GOA, IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231
  70. ↑ Identifiers.org
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