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Transferrine

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protéine

Resous ekstèn

identifiant Gran Enciclopèdia Catalana (ancien)
0147397
0142397
idantifyan sou Freebase
/m/02dcmf[1]
identifiant Microsoft Academic
22814914
identifiant RefSeq
NP_001054[2]
NP_001341633[2]
NP_001341632[2]
identifiant WordNet 3.1 d'un synset
15102484-n[3]
identifiant Ensembl de la protéine
ENSP00000385834[4]
ENSP00000401505[5]
ENSP00000417468[6]
ENSP00000418396[7]
ENSP00000418716[8]
ENSP00000419338[9]
ENSP00000419714[10]
identifiant DeCS
22302
identifiant OpenAlex
C22814914[11]
identifiant Bibliothèque nationale tchèque
ph323407

sous le nom: transferin

sens défini OmegaWiki
1495805
identifiant Grande Encyclopédie catalane
transferrina
identifiant UniProt d'une protéine
P02787[12]
identifiant Protein Data Bank
4X1D[13]
1A8E[13]
1A8F[13]
1B3E[13]
1BP5[13]
1BTJ[13]
1D3K[13]
1D4N[13]
1DTG[13]
1FQE[13]
1FQF[13]
1JQF[13]
1N7W[13]
1N7X[13]
1N84[13]
1OQG[13]
1OQH[13]
1RYO[13]
1SUV[13]
2HAU[13]
2HAV[13]
2O7U[13]
2O84[13]
3FGS[13]
3QYT[13]
3S9L[13]
3S9M[13]
3S9N[13]
3SKP[13]
3V83[13]
3V89[13]
3V8X[13]
3VE1[13]
4H0W[13]
4X1B[13]
5DYH[13]

se yon

proteyin[12]

pati de

Serotransferrin, mammalian[14]
Transferrin-like domain, protein family[15]
Transferrin family, iron binding site, protein family[15]

trouvé dans le taxon

Homo sapiens[12]

codé par

TF[12]

fonction moléculaire

ferric iron binding[16]

méthode de détermination: IEA

liaison ion métal[17]

méthode de détermination: IEA

liaison protéique[18][19][20][21][22][23][24][25][26][27]

méthode de détermination: IPI

ferric iron transmembrane transporter activity[16]

méthode de détermination: IEA

ferrous iron binding[28]

méthode de détermination: IDA

transferrin receptor binding[29][30][31]

méthode de détermination: TAS, IPI

iron chaperone activity[28]

méthode de détermination: IDA

composant cellulaire

recycling endosome[32]

méthode de détermination: IDA

vésicule[33]

méthode de détermination: IDA

HFE-transferrin receptor complex[34]

méthode de détermination: IDA

late endosome[32]

méthode de détermination: IDA

blood microparticle[35]

méthode de détermination: IDA

basal part of cell[32]

méthode de détermination: IDA

endocytic vesicle[36][37]

méthode de détermination: IDA

région extracellulaire[38][39][17][16][40]

méthode de détermination: NAS, IDA, IEA, TAS

surface cellulaire[41]

méthode de détermination: IDA

basal plasma membrane[32]

méthode de détermination: IDA

extrinsic component of external side of plasma membrane[42]

méthode de détermination: IGI

early endosome[32]

méthode de détermination: IDA

apical plasma membrane[43]

méthode de détermination: IDA

perinuclear region of cytoplasm[32][44]

méthode de détermination: IDA

clathrin-coated pit[45]

méthode de détermination: IDA

secretory granule lumen[38]

méthode de détermination: TAS

endosome membrane[38]

méthode de détermination: TAS

exosome[46][47][48]

méthode de détermination: IDA

milieu extracellulaire[49][50][51][52]

méthode de détermination: IDA, IEA

clathrin-coated vesicle membrane[38]

méthode de détermination: TAS

vésicule cytoplasmique[45]

méthode de détermination: IDA

endoplasmic reticulum lumen[38]

méthode de détermination: TAS

milieu extracellulaire[16][53][54][55]

méthode de détermination: HDA, IEA

exosome[56][57]

méthode de détermination: HDA

blood microparticle[58]

méthode de détermination: HDA

processus biologique

positive regulation of receptor-mediated endocytosis[42][59]

méthode de détermination: IDA, IGI

cellular response to iron ion[42]

méthode de détermination: IGI

regulation of protein stability[60]

méthode de détermination: TAS

transferrin transport[38]

méthode de détermination: TAS

iron ion homeostasis[17][61]

méthode de détermination: IC, IEA

platelet degranulation[38]

méthode de détermination: TAS

ion transport[17]

méthode de détermination: IEA

retina homeostasis[62]

méthode de détermination: IEP

iron ion transport[16]

méthode de détermination: IEA

cellular iron ion homeostasis[38][16]

méthode de détermination: TAS, IEA

organisation d'une membrane[38]

méthode de détermination: TAS

modification post-traductionnelle[38]

méthode de détermination: TAS

transport[63]

méthode de détermination: IEA

retina homeostasis[64]

méthode de détermination: HEP

iron ion transmembrane transport[65]

méthode de détermination: IEA

regulation of iron ion transport[42]

méthode de détermination: IGI

image du Gene Atlas

correspondance exacte

http://purl.uniprot.org/uniprot/P02787[66]

comprend

Transferrin family, iron binding site[14]
Transferrin-like domain[14]

Referans

  1. ↑ sauvegarde de la base de données Freebase, 28 oktòb 2013
  2. ↑ 2,0 2,1 et 2,2 NCBI Gene, 30 me 2020, 7018
  3. ↑ GF WordNet
  4. ↑ Ensembl Release 99, ENSP00000385834
  5. ↑ Ensembl Release 99, ENSP00000401505
  6. ↑ Ensembl Release 99, ENSP00000417468
  7. ↑ Ensembl Release 99, ENSP00000418396
  8. ↑ Ensembl Release 99, ENSP00000418716
  9. ↑ Ensembl Release 99, ENSP00000419338
  10. ↑ Ensembl Release 99, ENSP00000419714
  11. ↑ OpenAlex, 26 janvye 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  12. ↑ 12,0 12,1 12,2 et 12,3 UniProt, 13 novanm 2019, P02787
  13. ↑ 13,00 13,01 13,02 13,03 13,04 13,05 13,06 13,07 13,08 13,09 13,10 13,11 13,12 13,13 13,14 13,15 13,16 13,17 13,18 13,19 13,20 13,21 13,22 13,23 13,24 13,25 13,26 13,27 13,28 13,29 13,30 13,31 13,32 13,33 13,34 et 13,35 P02787, 9 out 2016, UniProt, angle
  14. ↑ 14,0 14,1 et 14,2 InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P02787
  15. ↑ 15,0 et 15,1 inferred from protein domain or family
  16. ↑ 16,0 16,1 16,2 16,3 16,4 et 16,5 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, InterPro, GOA
  17. ↑ 17,0 17,1 17,2 et 17,3 IEA, 8 avril 2019, P02787, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, UniProt
  18. ↑ IPI, 8 avril 2019, P02787, Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, UniProt
  19. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, IntAct protein interaction database, Structural basis for iron piracy by pathogenic Neisseria, GOA
  20. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, IntAct protein interaction database, Mechanism for multiple ligand recognition by the human transferrin receptor, GOA
  21. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, IntAct protein interaction database, Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax., GOA
  22. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, IntAct protein interaction database, How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH, GOA
  23. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, IntAct protein interaction database, The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin, GOA
  24. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, IntAct protein interaction database, The structural basis of transferrin sequestration by transferrin-binding protein B, GOA
  25. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, IntAct protein interaction database, Noncanonical interactions between serum transferrin and transferrin receptor evaluated with electrospray ionization mass spectrometry, GOA
  26. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, IntAct protein interaction database, Definition of the residues required for the interaction between glycine-extended gastrin and transferrin in vitro, GOA
  27. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, IntAct protein interaction database, Release of the soluble transferrin receptor is directly regulated by binding of its ligand ferritransferrin, GOA
  28. ↑ 28,0 et 28,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, British Heart Foundation, HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron, GOA
  29. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, British Heart Foundation, The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding, GOA
  30. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, British Heart Foundation, Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor, GOA
  31. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, British Heart Foundation, HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron, GOA
  32. ↑ 32,0 32,1 32,2 32,3 32,4 et 32,5 IDA, 8 avril 2019, P02787, Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, UniProt
  33. ↑ IDA, 8 avril 2019, P02787, A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, UniProt
  34. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, British Heart Foundation, Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor, GOA
  35. ↑ IDA, 17 oktòb 2017, P02787, Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P02787&geneProductId=UniProtKB:P02787, UniProt
  36. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, Mouse Genome Informatics, Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment, GOA
  37. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, Mouse Genome Informatics, Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes, GOA
  38. ↑ 38,00 38,01 38,02 38,03 38,04 38,05 38,06 38,07 38,08 et 38,09 TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, Reactome, GOA
  39. ↑ NAS, 8 avril 2019, P02787, The human plasma proteome: a nonredundant list developed by combination of four separate sources, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, UniProt
  40. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, British Heart Foundation, Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum, GOA
  41. ↑ IDA, 8 avril 2019, P02787, Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, UniProt
  42. ↑ 42,0 42,1 42,2 et 42,3 IGI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, British Heart Foundation, HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron, GOA
  43. ↑ IDA, 8 avril 2019, P02787, Truncated brush border myosin I affects membrane traffic in polarized epithelial cells, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, UniProt
  44. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, Community Assessment of Community Annotation with Ontologies, Ebola virus uses clathrin-mediated endocytosis as an entry pathway, GOA
  45. ↑ 45,0 et 45,1 IDA, 8 avril 2019, P02787, Myo6 facilitates the translocation of endocytic vesicles from cell peripheries, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, UniProt
  46. ↑ IDA, 17 oktòb 2017, P02787, Large-scale proteomics and phosphoproteomics of urinary exosomes, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P02787&geneProductId=UniProtKB:P02787, UniProt
  47. ↑ IDA, 17 oktòb 2017, P02787, In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P02787&geneProductId=UniProtKB:P02787, UniProt
  48. ↑ IDA, 17 oktòb 2017, P02787, Proteomic analysis of podocyte exosome-enriched fraction from normal human urine, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P02787&geneProductId=UniProtKB:P02787, UniProt
  49. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P02787&geneProductId=UniProtKB:P02787, 17 oktòb 2017, InterPro, GOA
  50. ↑ IDA, 17 oktòb 2017, P02787, Human colostrum: identification of minor proteins in the aqueous phase by proteomics, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P02787&geneProductId=UniProtKB:P02787, UniProt
  51. ↑ IDA, 17 oktòb 2017, P02787, Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P02787&geneProductId=UniProtKB:P02787, UniProt
  52. ↑ IDA, 17 oktòb 2017, P02787, Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P02787&geneProductId=UniProtKB:P02787, UniProt
  53. ↑ HDA, 8 avril 2019, P02787, Human colostrum: identification of minor proteins in the aqueous phase by proteomics, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, UniProt
  54. ↑ HDA, 8 avril 2019, P02787, Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, UniProt
  55. ↑ HDA, 8 avril 2019, P02787, Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, UniProt
  56. ↑ HDA, 8 avril 2019, P02787, Large-scale proteomics and phosphoproteomics of urinary exosomes, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, UniProt
  57. ↑ HDA, 8 avril 2019, P02787, In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, UniProt
  58. ↑ HDA, 8 avril 2019, P02787, Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, UniProt
  59. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, British Heart Foundation, Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells, GOA
  60. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, British Heart Foundation, CD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression, GOA
  61. ↑ IC, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, British Heart Foundation, HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron, GOA
  62. ↑ IEP, 17 oktòb 2017, P02787, Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P02787&geneProductId=UniProtKB:P02787, UniProt
  63. ↑ IEA, 17 oktòb 2017, P02787, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P02787&geneProductId=UniProtKB:P02787, UniProt
  64. ↑ HEP, 8 avril 2019, P02787, Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, UniProt
  65. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02787, 8 avril 2019, Gene Ontology Consortium, GOA
  66. ↑ Identifiers.org
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