natamycine
composé chimique
se yon
type d'entité chimique
sou-klas
polyene macrolide
structure chimique
masse
665,305 unité de masse atomique unifiée[2]
stéréoisomère de
formule chimique
C₃₃H₄₇NO₁₃[2]
SMILES canonique
CC1CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC3C(O3)C=CC(=O)O1)O)O)O)C(=O)O)OC4C(C(C(C(O4)C)O)N)O[2]
SMILES isomérique
C[C@@H]1C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@@H]3[C@H](O3)/C=C/C(=O)O1)O)O)O)C(=O)O)O[C@H]4[C@H]([C@H]([C@@H]([C@H](O4)C)O)N)O[2]
dose thérapeutique quotidienne
est le principe actif dans
Natacyn[28]
dénomination commune internationale des substances pharmaceutiques
natamycin[6]
trouvé dans le taxon
Streptomyces natalensis[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51]
Streptomyces gilvosporeus[52][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50]
Streptomyces chattanoogensis[30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50]
Streptomyces lydicus[30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50]
Streptomyces[53]
maladie traitée
conjonctivite[54]
coccidioïdomycose[54]
aspergillose[54]
mycose[54]
blépharite[54]
microsporidiose[54]
blastomycose[54]
candidose[54]
cryptococcose[54]
sporotrichose[54]
histoplasmose[54]
kératite[54]
catégorie Commons
Natamycin
Referans
- ↑ sauvegarde de la base de données Freebase, 28 oktòb 2013
- ↑ 2,0 2,1 2,2 2,3 2,4 2,5 et 2,6 PubChem, 17 novanm 2016, angle, 5284447, pimaricin
- ↑ 3,0 3,1 3,2 3,3 3,4 et 3,5 NCXMLFZGDNKEPB-FFPOYIOWSA-N, InChIKey
- ↑ 4,0 4,1 4,2 et 4,3 NCXMLFZGDNKEPB-BQGNJOPGSA-N, InChIKey
- ↑ 5,0 et 5,1 UniChem
- ↑ 6,0 et 6,1 ChEMBL, 19 janvye 2016, angle, Natamycin, CHEMBL1200656
- ↑ 7,0 7,1 7,2 7,3 et 7,4 DrugBank, angle, 17 novanm 2015, 00826, Natamycin
- ↑ 8,0 8,1 8,2 8,3 8,4 et 8,5 Global Substance Registration System, 17 novanm 2016, angle, natamycin, 8O0C852CPO
- ↑ OpenAlex, 26 janvye 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
- ↑ ChEMBL, 17 novanm 2016, angle, NATAMYCIN, CHEMBL1200656
- ↑ CAS Common Chemistry, 10 avril 2021, https://commonchemistry.cas.org/detail?cas_rn=7681-93-8, NCXMLFZGDNKEPB-FFPOYIOWSA-N
- ↑ 12,0 12,1 12,2 12,3 et 12,4 inferred from InChIKey
- ↑ ChEBI release 2020-09-01
- ↑ ChEBI release 2019-10-02
- ↑ ChEBI release 2021-03-01
- ↑ InChI=1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1, International Chemical Identifier
- ↑ base de données CosIng, 28 desanm 2019, 91607, NATAMYCIN, CAS no.: 7681-93-8
- ↑ https://list.essentialmeds.org/medicines/230, eEML - Electronic Essential Medicines List, 23 oktòb 2021
- ↑ Store norske leksikon, 5 jen 2020
- ↑ Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard
- ↑ base de données InfoCard de l'ECHA, 27 desanm 2018, 100.028.803, Natamycin, CAS no.: 7681-93-8
- ↑ ChemSpider, 17 novanm 2016, angle, 10468784, Natamycin
- ↑ DrugBank, angle, 17 novanm 2015, Natamycin, 00826
- ↑ inferred from InChI
- ↑ https://www.whocc.no/atc_ddd_index/?code=G01AA02
- ↑ https://www.whocc.no/atc_ddd_index/?code=A07AA03
- ↑ https://www.whocc.no/atc_ddd_index/?code=A01AB10
- ↑ RxNorm, 202743, 14 fevriye 2018
- ↑ The structure of the macrolide antibiotic pimaricin
- ↑ 30,0 30,1 30,2 et 30,3 Enhancement of natamycin production on Streptomyces gilvosporeus by chromosomal integration of the Vitreoscilla hemoglobin gene (vgb).
- ↑ 31,0 31,1 31,2 et 31,3 Bidirectional Regulation of AdpAch in Controlling the Expression of scnRI and scnRII in the Natamycin Biosynthesis of Streptomyces chattanoogensis L10.
- ↑ 32,0 32,1 32,2 et 32,3 Improvement of Natamycin Production by Cholesterol Oxidase Overexpression in Streptomyces gilvosporeus
- ↑ 33,0 33,1 33,2 et 33,3 Multiple transporters are involved in natamycin efflux in Streptomyces chattanoogensis L10.
- ↑ 34,0 34,1 34,2 et 34,3 Improvement of natamycin production by engineering of phosphopantetheinyl transferases in Streptomyces chattanoogensis L10.
- ↑ 35,0 35,1 35,2 et 35,3 Enhanced Natamycin production by Streptomyces natalensis in shake-flasks and stirred tank bioreactor under batch and fed-batch conditions
- ↑ 36,0 36,1 36,2 et 36,3 Physicochemical and microbial responses of Streptomyces natalensis HW-2 to fungal elicitor
- ↑ 37,0 37,1 37,2 et 37,3 Production of natamycin by Streptomyces gilvosporeus Z28 through solid-state fermentation using agro-industrial residues
- ↑ 38,0 38,1 38,2 et 38,3 Rational construction of genome-reduced and high-efficient industrial Streptomyces chassis based on multiple comparative genomic approaches
- ↑ 39,0 39,1 39,2 et 39,3 Complete Genome Sequence of the High-Natamycin-Producing Strain Streptomyces gilvosporeus F607.
- ↑ 40,0 40,1 40,2 et 40,3 WblAch, a pivotal activator of natamycin biosynthesis and morphological differentiation in Streptomyces chattanoogensis L10, is positively regulated by AdpAch
- ↑ 41,0 41,1 41,2 et 41,3 Effects of cultivation conditions on the production of natamycin with Streptomyces gilvosporeus LK-196.
- ↑ 42,0 42,1 42,2 et 42,3 Genome mining and homologous comparison strategy for digging exporters contributing self-resistance in natamycin-producing Streptomyces strains
- ↑ 43,0 43,1 43,2 et 43,3 Solubility properties and diffusional extraction behavior of natamycin from Streptomyces gilvosporeus biomass
- ↑ 44,0 44,1 44,2 et 44,3 Genome-wide analysis of the regulation of pimaricin production in Streptomyces natalensis by reactive oxygen species.
- ↑ 45,0 45,1 45,2 et 45,3 Construction of a Streptomyces lydicus A01 transformant with a chit42 gene from Trichoderma harzianum P1 and evaluation of its biocontrol activity against Botrytis cinerea.
- ↑ 46,0 46,1 46,2 et 46,3 Influence of fungal elicitors on biosynthesis of natamycin by Streptomyces natalensis HW-2
- ↑ 47,0 47,1 47,2 et 47,3 SlnM gene overexpression with different promoters on natamycin production in Streptomyces lydicus A02.
- ↑ 48,0 48,1 48,2 et 48,3 Characterization of type II thioesterases involved in natamycin biosynthesis in Streptomyces chattanoogensis L10.
- ↑ 49,0 49,1 49,2 et 49,3 Biosynthesis regulation of natamycin production from Streptomyces natalensis HDMNTE-01 enhanced by response surface methodology.
- ↑ 50,0 50,1 50,2 et 50,3 Identification of a secondary metabolism-responsive promoter by proteomics for over-production of natamycin in Streptomyces
- ↑ A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis
- ↑ Iteratively improving natamycin production in Streptomyces gilvosporeus by a large operon-reporter based strategy
- ↑ AB-400, a new tetraene macrolide isolated from Streptomyces costae
- ↑ 54,00 54,01 54,02 54,03 54,04 54,05 54,06 54,07 54,08 54,09 54,10 et 54,11 N0000146913, 13 desanm 2016, angle, NDF-RT
- ↑ 55,0 55,1 et 55,2 Inxight: Drugs Database, 2 novanm 2018, https://drugs.ncats.io/drug/8O0C852CPO, http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050514s009lbl.pdf
- ↑ 56,0 56,1 et 56,2 Medical Subject Headings, 15 mas 2018, D010866